Course overview
- Study period
- Semester 2, 2024 (22/07/2024 - 18/11/2024)
- Study level
- Undergraduate
- Location
- St Lucia
- Attendance mode
- In Person
- Units
- 2
- Administrative campus
- St Lucia
- Coordinating unit
- Chemistry & Molec Biosciences
Medicinal chemistry is a multidisciplinary science involving molecular design, chemical synthesis and bioassays followed by modifying compound properties for pharmaceutical applications. Medicinal chemistry thus combines organic chemistry with biochemistry, physical chemistry, microbiology, pharmacology, structural biology, computer modelling and molecular biology. Chemical biology involves the application of chemical techniques, analysis, and synthetic chemistry, to the study and manipulation of biological systems.
The course will use examples of successful drugs (e.g., antibiotics, antivirals, anti-inflammatory, anticancer etc) that impact on society to describe the key principles of drug design and discovery (structure, mechanism, analogues, fragment andᅠcomputational approaches to drug design; natural product leads; genomics/proteomics); key classes of drug targets (enzymes, carbohydrates, cell surface/cytosolic/nuclear proteins, nucleotides and genes); drug action (in vitroᅠbinding versus function, ligand receptor interactions, andᅠin vivoᅠactivity); and drug development (hit to lead to clinical candidate, rules for bioavailability and pharmacokinetics, pharmacodynamics, ADMET (absorption, distribution, metabolism, excretion, toxicity), drug delivery and formulation, drug profiling and personalised medicine).ᅠThe course will also coverᅠthe application of various chemical techniques, analysis, and synthetic chemistry, to the study and manipulation of biological systems.
Course requirements
Assumed background
CHEM2052 will cover the background knowledge that is assumed in the course.
Prerequisites
You'll need to complete the following courses before enrolling in this one:
CHEM2052 or ({CHEM2050 or CHEM2901} + BIOC2000)
Recommended prerequisites
We recommend completing the following courses before enrolling in this one:
CHEM2054 or CHEM2058 or SCIE2020 or BIOC2000
Incompatible
You can't enrol in this course if you've already completed the following:
CHEM3008
Course contact
Course staff
Lecturer
Timetable
The timetable for this course is available on the UQ Public Timetable.
Additional timetable information
Please checkᅠyour timetable regularly at the start of each semester.
Please check the location on your timetable before the first lecture, as this may change at short notice.
A schedule of the lectures in this subject will be provided in the Learning Resources folder on Blackboard.
Aims and outcomes
The course aims to provide students with a fundamental understanding of the principles ofᅠmedicinal chemistry and chemical biology.ᅠ
Students should:
1) gain an appreciation of the range of compounds used for medicinal/biological purposes and learn how to design novel compounds to modulate biological processes;ᅠ
2) develop an understanding of how these substances exert their biological activities;
3) acquire laboratory skills to assay biologically active compounds and determine their physicochemical properties.
ᅠ
Learning outcomes
After successfully completing this course you should be able to:
LO1.
understand how biologically active compounds are developed, as well as ethical and social issues associated with this process
LO2.
comprehend and apply medicinal chemistry principles and methods in critically analysing and interpreting research data
LO3.
discuss and explain physico-chemical and biological properties of compounds based on their structures
LO4.
apply your laboratory skills to assay biologically active compounds and determine their physico-chemical properties
LO5.
complete practical experiments within the stated deadlines and at a standard of performance commensurate with the expectations of students at this level of competence
LO6.
understand how to design molecules for specific biological functions
Assessment
Assessment summary
Category | Assessment task | Weight | Due date |
---|---|---|---|
Examination |
In-Semester Exam
|
15% |
2/09/2024 2:00 pm |
Tutorial/ Problem Set |
Written assessment
|
10% |
30/09/2024 2:00 pm |
Practical/ Demonstration |
Laboratory Reports
|
30% |
Week 4 Tue - Week 4 Wed Week 7 Tue - Week 7 Wed Week 12 Tue - Week 12 Wed
Tuesday practicals submit by 2pm on the following Tuesday, Wednesday practicals submit by 2pm on the following Wednesday. |
Examination |
End of semester exam
|
45% |
End of Semester Exam Period 2/11/2024 - 16/11/2024 |
A hurdle is an assessment requirement that must be satisfied in order to receive a specific grade for the course. Check the assessment details for more information about hurdle requirements.
Assessment details
In-Semester Exam
- Hurdle
- Identity Verified
- In-person
- Mode
- Written
- Category
- Examination
- Weight
- 15%
- Due date
2/09/2024 2:00 pm
Task description
The in-semester exam will consist of short-answer questions which will examine material presented in lectures in Module 1 of the course. More information will be provided during teaching activities and/or on Blackboard.
A single viewing session will be held AFTER any deferred examinations have taken place and have been marked, at a time when all the relevant examiners are available.
Use of Artificial Intelligence (AI)
This assessment task is to be completed in-person. The use of generative Artificial Intelligence (AI) tools will not be permitted. Any attempted use of generative AI may constitute student misconduct under the Student Code of Conduct.
Hurdle requirements
See ADDITIONAL COURSE GRADING INFORMATION for the hurdle/s relating to this assessment item.Exam details
Planning time | 10 minutes |
---|---|
Duration | 60 minutes |
Calculator options | (In person) Casio FX82 series or UQ approved , labelled calculator only |
Open/closed book | Closed Book examination - no written materials permitted |
Exam platform | Paper based |
Invigilation | Invigilated in person |
Submission guidelines
Deferral or extension
You may be able to defer this exam.
Written assessment
- Hurdle
- Team or group-based
- Mode
- Activity/ Performance, Written
- Category
- Tutorial/ Problem Set
- Weight
- 10%
- Due date
30/09/2024 2:00 pm
Task description
Worksheets or written tasks will be handed out during the contacts.
Use of Artificial Intelligence (AI)
This assessment task evaluates students' abilities, skills and knowledge without the aid of generative Artificial Intelligence (AI). Students are advised that the use of AI technologies to develop responses is strictly prohibited and may constitute student misconduct under the Student Code of Conduct.
Absence from a practical session:
You must attend 100% of the contact component of this course.
If you are unable to attend your timetabled contact session due to circumstances beyond your control (e.g., illness) you must submit a contact absence request immediately accompanied by acceptable supporting documentation that covers the date of the missed contact.
A list of acceptable reasons and required supporting documentation is found at https://my.uq.edu.au/information-and-services/manage-my-program/exams-and-assessment/applying-assessment-extension?p=1#1
Hurdle requirements
See ADDITIONAL COURSE GRADING INFORMATION for the hurdle/s relating to this assessment item.Submission guidelines
Written assessments will be submitted either via Blackboard or as directed by the lecturer.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 7 days. Extensions are given in multiples of 24 hours.
Applications for Extensions
Information on applying for an extension can be found here: my.UQ Applying for an extension.
Extension applications must be received by the assessment due date and time.
If you are unable to provide approved documentation to support your application by the due date and time, you must still submit your application by the deadline but with an attached Word document that outlines why you cannot provide the approved documentation by the deadline. You will then need to acquire and upload the approved documentation to your request within 24 hours. Please note: When an extension request has been submitted and is pending, students are expected to continue to work on the assessment item, with the aim of submitting by the requested due date and time.
Prolonged Absence
If you have been ill or unable to attend class for more than 14 days, we advise you to carefully consider whether you are capable of successfully completing your courses this semester.
Extensions with Student Access Plans (SAP)
For extensions up to 7 days, your SAP is all that is required as documentation to support your application. However, extension requests longer than 7 days (for any one assessment item) will require the submission of additional supporting documentation e.g. a medical certificate.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
You are required to submit assessable items on time. If you fail to meet the submission deadline for any assessment item, then 10% of the maximum possible mark for the assessment item (assessment ‘marked from’ value) will be deducted as a late penalty for every day (or part day) late after the due date. For example, if you submit your assignment 1 hour late, you will be penalised 10%; if your assignment is 24.5 hours late, you will be penalised 20% (because it is late by one 24-hour period plus part of another 24-hour period). 10% will be deducted per day for up to 7 calendar days, at which point your submission will receive a mark of zero (0) unless an extension has been approved.
In most instances one or more hurdles will apply to your assessment item so you will need to submit it to fulfil the requirements of the course regardless of how late it is and the mark you are likely to be awarded.
Laboratory Reports
- Hurdle
- Team or group-based
- In-person
- Mode
- Activity/ Performance, Written
- Category
- Practical/ Demonstration
- Weight
- 30%
- Due date
Week 4 Tue - Week 4 Wed
Week 7 Tue - Week 7 Wed
Week 12 Tue - Week 12 Wed
Tuesday practicals submit by 2pm on the following Tuesday, Wednesday practicals submit by 2pm on the following Wednesday.
Task description
Written reports based on wet-lab sessions. Students will complete three laboratory reports, one for each practical. The due date for the submission of these reports will be one week after the laboratory session(s) in that section or as directed by the lecturer.
Use of Artificial Intelligence (AI)
This assessment task evaluates students' abilities, skills and knowledge without the aid of generative Artificial Intelligence (AI). Students are advised that the use of AI technologies to develop responses is strictly prohibited and may constitute student misconduct under the Student Code of Conduct.
Absence from a practical session:
You must attend 100% of the practical component of this course.
If you are unable to attend your timetabled practical session due to circumstances beyond your control (e.g., illness) you must submit a practical absence request immediately accompanied by acceptable supporting documentation that covers the date of the missed workshop.
A list of acceptable reasons and required supporting documentation is found at https://my.uq.edu.au/information-and-services/manage-my-program/exams-and-assessment/applying-assessment-extension?p=1#1
Hurdle requirements
See ADDITIONAL COURSE GRADING INFORMATION for the hurdle/s relating to this assessment item.Submission guidelines
Laboratory reports are to be submitted electronically via Blackboard.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 7 days. Extensions are given in multiples of 24 hours.
Applications for Extensions
Information on applying for an extension can be found here: my.UQ Applying for an extension.
Extension applications must be received by the assessment due date and time.
If you are unable to provide approved documentation to support your application by the due date and time, you must still submit your application by the deadline but with an attached Word document that outlines why you cannot provide the approved documentation by the deadline. You will then need to acquire and upload the approved documentation to your request within 24 hours. Please note: When an extension request has been submitted and is pending, students are expected to continue to work on the assessment item, with the aim of submitting by the requested due date and time.
Prolonged Absence
If you have been ill or unable to attend class for more than 14 days, we advise you to carefully consider whether you are capable of successfully completing your courses this semester.
Extensions with Student Access Plans (SAP)
For extensions up to 7 days, your SAP is all that is required as documentation to support your application. However, extension requests longer than 7 days (for any one assessment item) will require the submission of additional supporting documentation e.g. a medical certificate.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
You are required to submit assessable items on time. If you fail to meet the submission deadline for any assessment item, then 10% of the maximum possible mark for the assessment item (assessment ‘marked from’ value) will be deducted as a late penalty for every day (or part day) late after the due date. For example, if you submit your assignment 1 hour late, you will be penalised 10%; if your assignment is 24.5 hours late, you will be penalised 20% (because it is late by one 24-hour period plus part of another 24-hour period). 10% will be deducted per day for up to 7 calendar days, at which point your submission will receive a mark of zero (0) unless an extension has been approved.
In most instances one or more hurdles will apply to your assessment item so you will need to submit it to fulfil the requirements of the course regardless of how late it is and the mark you are likely to be awarded.
End of semester exam
- Hurdle
- Identity Verified
- In-person
- Mode
- Written
- Category
- Examination
- Weight
- 45%
- Due date
End of Semester Exam Period
2/11/2024 - 16/11/2024
Task description
The exam will consist of short answer questions which will examine material presented in lectures and workshops from Modules 2-4. It is divided into 3 equally-weighted sections (one for each Module). More information will be provided during teaching activities and/or on Blackboard.
A single viewing session will be held AFTER any deferred/supplementary examinations have taken place and have been marked, at a time when all the relevant examiners are available.
Use of Artificial Intelligence (AI)
This assessment task is to be completed in-person. The use of generative Artificial Intelligence (AI) tools will not be permitted. Any attempted use of generative AI may constitute student misconduct under the Student Code of Conduct.
Hurdle requirements
See ADDITIONAL COURSE GRADING INFORMATION for the hurdle/s relating to this assessment item.Exam details
Planning time | 10 minutes |
---|---|
Duration | 120 minutes |
Calculator options | (In person) Casio FX82 series or UQ approved , labelled calculator only |
Open/closed book | Closed Book examination - no written materials permitted |
Exam platform | Paper based |
Invigilation | Invigilated in person |
Submission guidelines
Deferral or extension
You may be able to defer this exam.
Course grading
Full criteria for each grade is available in the Assessment Procedure.
Grade | Description |
---|---|
1 (Low Fail) |
Absence of evidence of achievement of course learning outcomes. Course grade description: Some engagement with the assessment tasks; however no demonstrated evidence of understanding of the concepts in the field of study The minimum percentage required for this grade is: 0% |
2 (Fail) |
Minimal evidence of achievement of course learning outcomes. Course grade description: Inability to apply knowledge and skills The minimum percentage required for this grade is: 30% |
3 (Marginal Fail) |
Demonstrated evidence of developing achievement of course learning outcomes Course grade description: Emerging ability to apply knowledge and skills The minimum percentage required for this grade is: 45% |
4 (Pass) |
Demonstrated evidence of functional achievement of course learning outcomes. Course grade description: Acceptable application of knowledge and skills The minimum percentage required for this grade is: 50% |
5 (Credit) |
Demonstrated evidence of proficient achievement of course learning outcomes. Course grade description: Effective application of knowledge and skills The minimum percentage required for this grade is: 65% |
6 (Distinction) |
Demonstrated evidence of advanced achievement of course learning outcomes. Course grade description: Extensive application of knowledge and skills The minimum percentage required for this grade is: 75% |
7 (High Distinction) |
Demonstrated evidence of exceptional achievement of course learning outcomes. Course grade description: Original, novel and/or creative application of knowledge and skills The minimum percentage required for this grade is: 85% |
Additional course grading information
Assessment Hurdles
In order to pass this course, you must meet ALL of the following requirements (if you do not meet these requirements, the maximum grade you will receive will be a 3):
1. You must obtain an overall course mark of 50% or more; and
2. You must obtain a weighted average mark of 40% or more across the two examination components; and
3. You must obtain a minimum weighted average mark of 40% across all other non-examination course assessment items and learning tasks.
4.ᅠYou must complete 100% of the laboratory and workshop components of the course (both practical and assessment).
The maximum grade you will receive will be a 2 if you:
1. Obtain a weighted average mark of 30% or less across the two examination components; and/or
2. Obtain a weighted average mark of 30% or less across the non-examination course assessment items and learning tasks.
Supplementary assessment
Supplementary assessment is available for this course.
Should you fail a course with a grade of 3, you may be eligible for supplementary assessment. Refer to my.UQ for information on supplementary assessment and how to apply.
Supplementary assessment provides an additional opportunity to demonstrate you have achieved all the required learning outcomes for a course.
If you apply and are granted supplementary assessment, the type of supplementary assessment set will consider which learning outcome(s) have not been met.
Supplementary assessment can take any form (such as a written report, oral presentation, examination or other appropriate assessment) and may test specific learning outcomes tailored to the individual student, or all learning outcomes.
To receive a passing grade of 3S4, you must obtain a mark of 50% or more on the supplementary assessment.
Additional assessment information
Assessment Submission
It is the responsibility of the student to ensure the on time, correct and complete submission of all assessment items.
Please ensure you receive and save the submission confirmation for all submitted items, you may be asked to produce this as evidence of your submission.
Turnitin
By submitting work through Turnitin you are deemed to have accepted the following declaration “I certify that this assignment is my own work and has not been submitted, either previously or concurrently, in whole or in part, to this University or any other educational institution, for marking or assessment”.
All students must ensure they receive their Turnitin receipt on submission of any assessments. A valid Turnitin receipt will be the only evidence accepted if one or more of your submissions are missing. Without evidence, the assessment will receive the standard late penalty, or after seven days, will receive zero. In the case of a Blackboard outage, please contact the Course Coordinator as soon as possible to confirm the outage with ITS.
Assessment/Attendance
Please notify your Course Coordinator as soon as you become aware of any issue that may affect your ability to meet the assessment/attendance requirements of the course. The my.UQ website and the Electronic Course Profile (ECP) for your course also provide information about your course requirements, the rules associated with your courses and services offered by the University.
A note for repeating students in this course
Any student who enrols in a course must not be given exemption or partial credit from their previous attempt(s) for any individual piece of assessment. Instead, the student must successfully complete all of the learning activities and assessment items within the study period of enrolment (PPL Assessment - Procedures Section: Assessment integrity).
If the same assessment item is set from one year to the next, repeating students are allowed to submit the same work they submitted in previous attempts at the course. Where possible SCMB recommends that you use the feedback you received in your last attempt to improve parts of the item where you lost marks. Resubmission of an altered or unaltered assessment item by a repeating student (where the same assessment has been set) will not be considered as self-plagiarism.
Important Note
Turnitin is to be used for assignments/laboratory reports to check for plagiarism. Penalties can be severe for plagiarism.
The University has adopted the following definition of plagiarism: Plagiarism is the act of misrepresenting as one's own original work the ideas, interpretations, words or creative works of another either intentionally or unintentionally. These include published and unpublished documents, designs, music, sounds, images, photographs, computer codes and ideas gained through working in a group. These ideas, interpretations, words or works may be found in print and/or electronic media.
Students are encouraged to read the UQ Academic Integrity and Plagiarism policy.
Learning resources
You'll need the following resources to successfully complete the course. We've indicated below if you need a personal copy of the reading materials or your own item.
Library resources
Find the required and recommended resources for this course on the UQ Library website.
Additional learning resources information
Blackboard ᅠ Additional material (lecture notes for CHEM2052) can be found on the Blackboard site for CHEM3020 at learn.uq.edu.au. ᅠ Please check the Announcements section of the Blackboard site regularly for information updates.
Notes and other essential resources will be provided through the Blackboard web site only and will not be distributed in class.ᅠ Students are required to access this information for themselves.ᅠ Other reading may be recommended by individual lecturers.
ᅠ
Learning activities
The learning activities for this course are outlined below. Learn more about the learning outcomes that apply to this course.
Filter activity type by
Please select
Learning period | Activity type | Topic |
---|---|---|
Multiple weeks From Week 1 To Week 13 |
Lecture |
Lectures Course content will be delivered by Dr Stephenson, Prof. Ferro, Prof. Blanchfield and Prof. Schenk, with specialist lectures delivered by Dr Zuegg and A/Prf Paterson. A detailed list of lectures will be placed on the CHEM3020 Blackboard site (Learning Resources), along with basic notes that the student should supplement (build on) through lecture viewing and reading of recommended resources (see Section 3.2 of this ECP). |
Multiple weeks From Week 2 To Week 11 |
Practical |
Laboratory Practicals Laboratory (wet-lab) practicals will be held in Weeks 2-3 and 5-6 in the level 5 Chemistry Laboratories, and in Weeks 10-11 in the level 4 Chemistry Laboratories. |
Multiple weeks From Week 8 To Week 9 |
General contact hours |
Contacts Contacts (computer lab) will be held in Weeks 8-9 (see Blackboard for more details). |
Policies and procedures
University policies and procedures apply to all aspects of student life. As a UQ student, you must comply with University-wide and program-specific requirements, including the:
- Student Code of Conduct Policy
- Student Integrity and Misconduct Policy and Procedure
- Assessment Procedure
- Examinations Procedure
- Reasonable Adjustments - Students Policy and Procedure
Learn more about UQ policies on my.UQ and the Policy and Procedure Library.
You'll also need to be aware of the following policies and procedures while completing this course:
- Laboratory Occupational Health and Safety