Course coordinator
Dr Ben Ross
Post content-related questions to the Discussion Board. To discuss other matters, please email first to make an appointment.
Course overview
- Study period
- Semester 2, 2024 (22/07/2024 - 18/11/2024)
- Study level
- Undergraduate
- Location
- Dutton Park
- Attendance mode
- In Person
- Units
- 2
- Administrative campus
- Dutton Park
- Coordinating unit
- Pharmacy School
Design strategies & structure activity relationships of drugs used to treat endocrine, inflammatory, allergic and psychiatric disorders. Theory & techniques of drug identification & analysis, including quantitative analysis of drugs. Concepts related to the control of doping in sport.
This course aims to familiarise students with design strategies and structure-activity relationships of a selection of drugs used in the treatment of endocrine, inflammatory, allergic and psychiatric disorders. The theory and techniques of drug identification and analysis, including the quantitative analysis of drugs, will be covered. Concepts related to the control of doping in sport will be discussed including the role of analytical chemistry, regulatory bodies, and the legitimacy of specific medications in sport.
Course requirements
Assumed background
PHRM2040 Drug discovery A1 and first year chemistry are desirable background for Drug Discovery A2. An understanding of fundamental chemical structures, functional groups, and the principles of drug design are required. Students should have a good understanding of basic statistical analysis and be competent at pharmaceutical calculations.
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Restrictions
Restricted to Bachelor of Pharmacy (Honours) students only.
Course contact
Course staff
Lecturer
Laboratory manager
Ms Sue Therkelsen
Timetable
The timetable for this course is available on the UQ Public Timetable.
Additional timetable information
For scheduled times and venues, refer to the mySI-net timetable. The topic of each lecture / practical / tutorial and other supporting information can be found on Blackboard.
Aims and outcomes
The aim of this course is to demonstrate the fundamental importance of drug design and structure-activity relationships, by building on the concepts that were introduced in PHRM2040 Drug Discovery A1 studied in Semester One. The course also aims to highlight the significance of drug analysis and doping control in sport.
Learning outcomes
After successfully completing this course you should be able to:
LO1.
explain at an advanced level the role of molecular modifications in therapeutics, as an extension of Drug Discovery A1 studied in first semester.
LO2.
identify and explain key structure-activity relationships for drugs used to treat endocrine, inflammatory, allergic and psychiatric disorders.
LO3.
explain the theoretical basis of analytical techniques used for routine drug analysis and pharmaceutical quality control, process and interpret the generated data, and perform analytical calculations.
LO4.
produce the structures of drugs by interpreting and analysing spectroscopic and spectrometric data including a combination of information from multiple analytical sources.
LO5.
explain the role of analytical chemistry in drug testing within sport; identify the regulatory bodies for the control of doping in sport; identify, interpret and recall information useful in counselling professional athletes on the legitimacy of specific substances and methods in sport.
Assessment
Assessment summary
| Category | Assessment task | Weight | Due date |
|---|---|---|---|
| Paper/ Report/ Annotation, Practical/ Demonstration |
Drug Analysis Laboratory Worksheet
|
20% |
5/08/2024 12:00 pm
(Submitted to the demonstrator at the end of the practical class) |
| Quiz |
Drug Analysis Online Open-Book Quiz
|
20% |
2/09/2024 5:00 pm
(Complete the quiz anytime in the 7 days prior to this deadline) |
| Presentation | Drug Analysis/Med Chem Sports Doping Video | 40% |
1/10/2024 5:00 pm |
| Quiz |
Med Chem Online Open-Book Quiz
|
20% |
25/10/2024 5:00 pm
(Complete the quiz anytime in the 7 days prior to this deadline) |
Assessment details
Drug Analysis Laboratory Worksheet
- Identity Verified
- In-person
- Mode
- Activity/ Performance, Written
- Category
- Paper/ Report/ Annotation, Practical/ Demonstration
- Weight
- 20%
- Due date
5/08/2024 12:00 pm
(Submitted to the demonstrator at the end of the practical class)
- Other conditions
- Time limited.
- Learning outcomes
- L03
Task description
- This task has been designed to be challenging, authentic and complex. Whilst students may use Artificial Intelligence (AI) technologies, successful completion of assessment in this course will require students to critically engage in specific contexts and tasks for which artificial intelligence will provide only limited support and guidance. A failure to reference generative AI use may constitute student misconduct under the Student Code of Conduct. To pass this assessment, students will be required to demonstrate detailed comprehension of their written submission independent of AI tools.
- Students work individually on a drug analysis practical task in the PACE Level 5 laboratory and complete a worksheet displaying their data, calculations, discussion and answers to questions about drug analysis theory. The PHRM2041 Laboratory Manual, which is available on Learn.UQ (Blackboard), contains the details of the task and the associated worksheet. Each student must submit their completed worksheet to the demonstrator by the end of the practical class.
- Please refer to the Learn.UQ (Blackboard) site for additional information.
Submission guidelines
Submission: The worksheet must be submitted to the demonstrator at the end of the practical class.
Resubmission: Students who have not achieved a pass (i.e. obtain less than 50% of available marks) will be offered one opportunity to resubmit; the maximum grade that can be achieved for the resubmission will be a pass (50% of available marks). No extension is available on the due date for a resubmission.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 28 days. Extensions are given in multiples of 24 hours.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
Drug Analysis Online Open-Book Quiz
- Online
- Mode
- Written
- Category
- Quiz
- Weight
- 20%
- Due date
2/09/2024 5:00 pm
(Complete the quiz anytime in the 7 days prior to this deadline)
- Other conditions
- Time limited.
- Learning outcomes
- L03, L04, L05
Task description
- This task has been designed to be challenging, authentic and complex. Whilst students may use Artificial Intelligence (AI) technologies, successful completion of assessment in this course will require students to critically engage in specific contexts and tasks for which artificial intelligence will provide only limited support and guidance. To pass this assessment, students will be required to demonstrate detailed comprehension of their submission independent of AI tools.
- This online open-book quiz assesses the Module 1 Drug Analysis topics.
- The format may be a mixture of question types, including multiple choice, multiple answer, matching, ordering, fill in the blank/s, jumbled sentence/s, either/or (e.g. true/false), short answer, and short essay style questions.
- Questions may be provided randomly from a pool, in which case each student may receive a different but equivalent quiz.
- The quiz duration is 10 minutes reading time + 50 minutes working time, resulting in a time limit of 60 min in total, after which your answers will be saved and submitted automatically (unless you submit them sooner manually). You can commence working on your quiz during reading time. The timer will continue to run if you exit quiz.
- Only one attempt is permitted.
- Please refer to the Learn.UQ (Blackboard) site for additional information.
Submission guidelines
Submission: The quiz will be completed electronically in the Learn.UQ (Blackboard) site for this course.
Resubmission: Students who have not achieved a pass (i.e. obtain less than 50% of available marks) will be offered one opportunity to resubmit; the maximum grade that can be achieved for the resubmission will be a pass (50% of available marks). No extension is available on the due date for a resubmission.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 28 days. Extensions are given in multiples of 24 hours.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
Drug Analysis/Med Chem Sports Doping Video
- Mode
- Oral, Product/ Artefact/ Multimedia
- Category
- Presentation
- Weight
- 40%
- Due date
1/10/2024 5:00 pm
- Learning outcomes
- L01, L02, L03, L04, L05
Task description
- This assessment is a video presentation that involves applying the concepts covered in Modules 1 and 2, using data, spectra and other information provided by the Course Coordinator. In this scenario you are a pharmacist working as a consultant to Sport Integrity Australia. You are asked to analyse suspicious chemical substances found in containers hidden inside the athletes' village of a major sporting event. Your task is to identify the substances and determine if they are permitted or banned in professional sport. You are also asked to analyse blood samples taken from an athlete competing at the event to check for the presence and concentration of banned substances. You explain your findings to the Investigations Committee of Sport Integrity Australia in a PowerPoint presentation, which is recorded, and the video submitted as this assessment item.
- Your camera must be turned on and your face visible during the entire presentation video. Students who do not comply with this requirement will receive a maximum of 50% of the available marks.
- A PDF of the PowerPoint slides must also be submitted.
- You must reference the sources of the information that you include in your presentation using the author-date referencing system, specifically the APA 7th referencing style from the American Psychological Association.
- Please refer to the Learn.UQ (Blackboard) site for further information.
- This task has been designed to be challenging, authentic and complex. Whilst students may use Artificial Intelligence (AI) technologies, successful completion of assessment in this course will require students to critically engage in specific contexts and tasks for which artificial intelligence will provide only limited support and guidance. A failure to reference generative AI use may constitute student misconduct under the Student Code of Conduct. To pass this assessment, students will be required to demonstrate detailed comprehension of their written submission independent of AI tools.
Submission guidelines
Submission: A video file and PDF of the PowerPoint slides will be submitted electronically via the Learn.UQ (Blackboard) site for this course.
Resubmission: Students who have not achieved a pass (i.e. obtain less than 50% of available marks) will be offered one opportunity to resubmit; the maximum grade that can be achieved for the resubmission will be a pass (50% of available marks). No extension is available on the due date for a resubmission.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 28 days. Extensions are given in multiples of 24 hours.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
Med Chem Online Open-Book Quiz
- Online
- Mode
- Written
- Category
- Quiz
- Weight
- 20%
- Due date
25/10/2024 5:00 pm
(Complete the quiz anytime in the 7 days prior to this deadline)
- Other conditions
- Time limited.
- Learning outcomes
- L01, L02
Task description
- This task has been designed to be challenging, authentic and complex. Whilst students may use Artificial Intelligence (AI) technologies, successful completion of assessment in this course will require students to critically engage in specific contexts and tasks for which artificial intelligence will provide only limited support and guidance. To pass this assessment, students will be required to demonstrate detailed comprehension of their submission independent of AI tools.
- This online open-book quiz assesses the Module 2 Medicinal Chemistry topics.
- The format may be a mixture of question types, including multiple choice, multiple answer, matching, ordering, fill in the blank/s, jumbled sentence/s, either/or (e.g. true/false), short answer, and short essay style questions.
- Questions may be provided randomly from a pool, in which case each student may receive a different but equivalent quiz.
- The quiz duration is 10 minutes reading time + 50 minutes working time, resulting in a time limit of 60 min in total, after which your answers will be saved and submitted automatically (unless you submit them sooner manually). You can commence working on your quiz during reading time. The timer will continue to run if you exit quiz.
- Only one attempt is permitted.
- Please refer to the Learn.UQ (Blackboard) site for additional information.
Submission guidelines
Submission: The quiz will be completed electronically in the Learn.UQ (Blackboard) site for this course.
Resubmission: Students who have not achieved a pass (i.e. obtain less than 50% of available marks) will be offered one opportunity to resubmit; the maximum grade that can be achieved for the resubmission will be a pass (50% of available marks). No extension is available on the due date for a resubmission.
Deferral or extension
You may be able to apply for an extension.
The maximum extension allowed is 28 days. Extensions are given in multiples of 24 hours.
Late submission
A penalty of 10% of the maximum possible mark will be deducted per 24 hours from time submission is due for up to 7 days. After 7 days, you will receive a mark of 0.
Course grading
Full criteria for each grade is available in the Assessment Procedure.
| Grade | Cut off Percent | Description |
|---|---|---|
| 1 (Low Fail) | 1 - 29 |
Absence of evidence of achievement of course learning outcomes. |
| 2 (Fail) | 30 - 44 |
Minimal evidence of achievement of course learning outcomes. |
| 3 (Marginal Fail) | 45 - 49 |
Demonstrated evidence of developing achievement of course learning outcomes |
| 4 (Pass) | 50 - 64 |
Demonstrated evidence of functional achievement of course learning outcomes. |
| 5 (Credit) | 65 - 74 |
Demonstrated evidence of proficient achievement of course learning outcomes. |
| 6 (Distinction) | 75 - 84 |
Demonstrated evidence of advanced achievement of course learning outcomes. |
| 7 (High Distinction) | 85 - 100 |
Demonstrated evidence of exceptional achievement of course learning outcomes. |
Supplementary assessment
Supplementary assessment is available for this course.
Additional assessment information
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Learning resources
You'll need the following resources to successfully complete the course. We've indicated below if you need a personal copy of the reading materials or your own item.
Library resources
Find the required and recommended resources for this course on the UQ Library website.
Other course materials
If we've listed something under further requirement, you'll need to provide your own.
Required
| Item | Description | Further Requirement |
|---|---|---|
| Laboratory coat (white) | For your health and safety, you will not be allowed to enter the laboratory without this item. | own item needed |
| Safety glasses | For your health and safety, you will not be allowed to enter the laboratory without this item. | own item needed |
| Calculator | Casio FX82 series or UQ approved (labelled) calculator only | own item needed |
Additional learning resources information
Zoom: Access to Zoom via your UQ student account will be required for certain synchronous online classes each week (workshops).
Learning activities
The learning activities for this course are outlined below. Learn more about the learning outcomes that apply to this course.
Filter activity type by
Please select
| Learning period | Activity type | Topic |
|---|---|---|
Multiple weeks From Week 1 To Week 6 |
Not Timetabled |
Module 1: Drug Analysis Content Students engage with Module 1 Drug Analysis content via the Learn.UQ (Blackboard) site, including videos, reading material, and homework questions. This covers the theory and techniques of drug identification and analysis, including quantitative analysis of drugs and concepts related to the control of doping in sport. Learning outcomes: L03, L04, L05 |
Multiple weeks From Week 2 To Week 6 |
Workshop |
Module 1: Drug Analysis Workshops These online workshops are an opportunity to discuss and ask questions about the weekly Module 1 Drug Analysis topics. Use the link on the Learn.UQ (Blackboard) site to attend via Zoom. Learning outcomes: L03, L04, L05 |
Week 3 (05 Aug - 11 Aug) |
Practical |
Module 1: Drug Analysis Practical In this practical class held in the laboratory, students develop skills in quantitative drug analysis by completing a quality control test of a batch of tablets to determine drug content. Learning outcomes: L03, L04, L05 |
Multiple weeks From Week 7 To Week 9 |
Workshop |
Modules 1 & 2: Sports Doping Video Workshops These workshops are an opportunity to discuss and ask questions about the Drug Analysis/Med Chem Sports Doping Video Assessment. Use the link on the Learn.UQ (Blackboard) site to attend via Zoom. Learning outcomes: L01, L02, L03, L04, L05 |
Multiple weeks From Week 7 To Week 13 |
Not Timetabled |
Module 2: Medicinal Chemistry Content Students engage with Module 2 Medicinal Chemistry content via the Learn.UQ (Blackboard) site, including videos, reading material, and homework questions. This covers the design and structure activity relationships of drugs used to treat endocrine, inflammatory, allergic and psychiatric disorders. Learning outcomes: L01, L02 |
Multiple weeks From Week 8 To Week 13 |
Workshop |
Module 2: Medicinal Chemistry Workshops These online workshops are an opportunity to discuss and ask questions about the weekly Module 2 Medicinal Chemistry topics. Use the link on the Learn.UQ (Blackboard) site to attend via Zoom. Learning outcomes: L01, L02 |
Policies and procedures
University policies and procedures apply to all aspects of student life. As a UQ student, you must comply with University-wide and program-specific requirements, including the:
- Student Code of Conduct Policy
- Student Integrity and Misconduct Policy and Procedure
- Assessment Procedure
- Examinations Procedure
- Reasonable Adjustments - Students Policy and Procedure
Learn more about UQ policies on my.UQ and the Policy and Procedure Library.
You'll also need to be aware of the following policies and procedures while completing this course:
- Laboratory Occupational Health and Safety
- Incidental Student Fees and Charges